Scientific Reports：以锻炼对抗肥胖基因

Hudson Reddon和David Meyre

麦克马斯特大学（McMaster University）研究人员发现，世界各地的人们都可以通过身体活动活跃的生活方式（physically active lifestyle）来减弱遗传性肥胖基因的影响。

在2016年1月4日发表于《Scientific Reports》的论文中，David Meyre和他的团队表明，身体活动活跃的生活方式能够大幅降低主要肥胖基因FTO对体重的基因效应。

“这为携带肥胖易感基因的人们提供了希望的信息，他们能够’有所作为’。我们体重的命运不仅书写在基因蓝图之中”麦克马斯特大学Michael G. DeGroote医学院临床流行病学和生物统计学副教授Meyre说道。

Hudson Reddon和David Meyre

他的团队研究了来自6个族群（南亚、东亚、欧洲、非洲、拉丁美洲和北美原住民）多达17400人的数据，这些人招募自17个国家，随访超过3年。

“为了加强结果的可信度，我们同时使用基本的和精确的（代谢当量评分）身体活动测量手段，并且将传统的身体质量指数与最近开发的身体肥胖指数相比较”该研究第一作者、临床流行病学和生物统计学系博士生Hudson Reddon说道。

他们分析了14个肥胖易感基因的影响，发现身体活动能够减弱FTO（常见肥胖的主要因素）的基因效应达75%。

“这些有前景的结果激励我们研究其他的生活方式因素，如饮食、压力和睡眠模式，可能如何影响肥胖的遗传易感性”Meyre说道。（生物谷 Bioon.com）

DOI： 10.1038/srep18672

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

Physical activity (PA) has been shown to reduce the impact of FTO variation and obesity genetic risk scores (GRS) on BMI. We examined this interaction using a quantitative measure of PA and two adiposity indexes in a longitudinal multi-ethnic study. We analyzed the impact of PA on the association between 14 obesity predisposing variants (analyzed independently and as a GRS) and baseline/follow-up obesity measures in the multi-ethnic prospective cohort EpiDREAM (17423 participants from six ethnic groups). PA was analyzed using basic (low-moderate-high) and quantitative measures (metabolic equivalents (METS))， while BMI and the body adiposity index (BAI) were used to measure obesity. Increased PA was associated with decreased BMI/BAI at baseline/follow-up. FTO rs1421085， CDKAL1rs2206734， TNNl3K rs1514176， GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up. Risk alleles of three SNPs displayed nominal associations with increased (NTRK2 rs1211166， BDNFrs1401635) or decreased (NPC1 rs1805081) basic PA score independently of BMI/BAI. Both basic and quantitative PA measures attenuated the association between FTO rs1421085 risk allele and BMI/BAI at baseline and follow-up. Our results show that physical activity can blunt the genetic effect of FTO rs1421085 on adiposity by 36-75% in a longitudinal multi-ethnic cohort.